Open AccessNano-Iron Oxide Supported on the Printed Electrode for Voltammetric Determination of Manidipine on a Very Small Sample in Different Media: Analytical and Clinical Purposes
Author(s) -
Hassan A.M. Hendawy,
Alaa S. Amin,
Mai Aish,
Said Moalla
Publication year - 2021
Publication title -
journal of the electrochemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.258
H-Index - 271
eISSN - 1945-7111
pISSN - 0013-4651
DOI - 10.1149/1945-7111/ac3714
Subject(s) - ascorbic acid , electrode , reproducibility , cyclic voltammetry , scanning electron microscope , electrochemistry , materials science , voltammetry , chemistry , nano , analytical chemistry (journal) , chromatography , composite material , food science
In this work, a sensitive and selective voltammetric determination for Manidipine in pharmaceutical formulations and biological fluids have been studied based on the enhanced electrochemical response at surface nano-iron oxide modified screen-printed electrode, Scanning electron microscopy (SEM) and cyclic voltammetry (CV) were used to confirm the morphology, structure of the as-prepared nanospheres electrochemical characterizations different modified electrodes. The modified nano iron oxide modified printed electrode (FSPE) exhibits voltammetric with high sensitivity, stability, and its applicability over a wide range for the determination of MAN in 0.04 M universal buffer (pH = 4.00 ± 0.01), SWV method shows linearity over the concentration range 60–925 nM. LOD and LOQ are 8.5nM and 28.4 nM respectively. The statistical validation comparison with the reported technique was also performed for the determination of MAN in authentic and pharmaceutical formulations. Moreover, the modified nano-screen printing sensor showed fine selectivity, reproducibility, and stability, and it was successfully used for the simultaneous determination of MAN in the presence of ascorbic acid and uric acid in dentate urine samples with appropriate results.