Open AccessDisposable Stochastic Sensor Based on Deposition of a Nanolayer of Silver on Silk for Molecular Recognition of Specific Biomarkers
Author(s) -
RalucaIoana Stefanvan Staden,
Sorin Sebastian Gheorghe,
RuxandraMaria IlieMihai,
Marius Bădulescu
Publication year - 2021
Publication title -
journal of the electrochemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.258
H-Index - 271
eISSN - 1945-7111
pISSN - 0013-4651
DOI - 10.1149/1945-7111/abeea2
Subject(s) - silk , molecular recognition , coating , materials science , deposition (geology) , analyte , electrode , nanotechnology , biomedical engineering , chemistry , chromatography , composite material , molecule , organic chemistry , biology , medicine , paleontology , sediment
A cold plasma system was used for Silver nanofilm coating of silk material. The Silver coated material was further modified by soaking in a 10 −3 mol l −1 solution of α -cyclodextrin. The modified silk material was served as working electrode for simultaneous molecular recognition of specific biomarkers. CA19-9, CEA and p53 served as model analytes to prove that the disposable stochastic sensor can be used for simultaneous molecular recognition of specific biomarkers. The signatures (t off value) obtained for p53, CEA and CA19-9 were different, proving that the proposed disposable stochastic sensor is selective, and can be used for molecular recognition of these biomarkers in whole blood and tumoral tissue samples.