Electrochemical Determination of Metronidazole Using a Glassy Carbon Electrode Modified with Nanoporous Bimetallic Carbon Derived from a ZnCo-Based Metal-Organic Framework | Zendy

Yiliyasi Baikeli | Zendy; Xamxikamar Mamat | Zendy; Mailidan Wumaer | Zendy; Muhebaiti Muhetaer | Zendy; Haji Akbar Aisa | Zendy; Guangzhi Hu | Zendy

Open Access

Electrochemical Determination of Metronidazole Using a Glassy Carbon Electrode Modified with Nanoporous Bimetallic Carbon Derived from a ZnCo-Based Metal-Organic Framework

Author(s) -

Yiliyasi Baikeli,

Xamxikamar Mamat,

Mailidan Wumaer,

Muhebaiti Muhetaer,

Haji Akbar Aisa,

Guangzhi Hu

Publication year - 2020

Publication title -

journal of the electrochemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.258

H-Index - 271

eISSN - 1945-7111

pISSN - 0013-4651

DOI - 10.1149/1945-7111/ab9d94

Subject(s) - nanoporous , bimetallic strip , materials science , electrochemistry , carbonization , linear sweep voltammetry , carbon fibers , glassy carbon , chemical engineering , specific surface area , electrochemical gas sensor , cyclic voltammetry , electrode , inorganic chemistry , metal , chemistry , composite number , nanotechnology , metallurgy , organic chemistry , composite material , catalysis , scanning electron microscope , engineering

ZnCo-based metal-organic frameworks (MOFs) based on ZIF-8 and ZIF-67 were synthesized at room temperature. Direct carbonization of the ZnCo-MOF under nitrogen atmosphere produced a nanoporous ZnCo/C composite which exhibited a large surface area (1111.499 m 2 ∙g −1 ) and narrow pore-size distribution (1 ∼ 2 nm). A glassy carbon electrode was modified with the nanoporous ZnCo/C and Nafion for the electrochemical determination of the antibiotic metronidazole by linear sweep voltammetry. Under optimal conditions, the reduction peak current (observed at −0.66 V vs Ag/AgCl) increased linearly with increasing metronidazole concentration in the range of 0.05–100 μ M, with a detection limit estimated at 17 nM. These results are attributed to the large surface area, porous structure, high nitrogen content, and synergistic effects of the Zn and Co constituents. The sensor was satisfactorily used for metronidazole analysis in pharmaceutical samples.

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