Open AccessPolymer-Modified Carbon Fiber Microelectrodes for Neurochemical Detection of Dopamine and Metabolites
Author(s) -
Pauline Wonnenberg,
Alexander G. Zestos
Publication year - 2020
Publication title -
ecs transactions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.235
H-Index - 52
eISSN - 1938-6737
pISSN - 1938-5862
DOI - 10.1149/09707.0901ecst
Subject(s) - neurochemical , microelectrode , cyclic voltammetry , dopamine , electrode , biosensor , chemistry , polymer , voltammetry , materials science , nanotechnology , organic chemistry , electrochemistry , neuroscience , biology
Carbon-fiber microelectrodes (CFMEs) are considered to be the standard electrodes for neurotransmitter detection. Fast-scan cyclic voltammetry (FSCV), an electro analytical method, has the ability to follow neurochemical dynamics in real time using CFMEs. Improvements in neurochemical detection with CFMEs were previously made through the coating of polymers onto the surface of the carbon-fiber. Polymers such as PEI, PEDOT, and Nafion were electrodeposited onto the surface of the electrodes to enhance neurochemical detection. This work demonstrates applications for enhancements in co-detection of similarly structured neurochemicals such as dopamine, DOPAL, 3-methoxytyramine, DOPAC, and other neurotransmitters. Manipulating the charge and surface structure of the carbon electrode allows for the improvement of sensitivity and selectivity of neurotransmitter detection. The analytes are detected and differentiated by the shape and the peak positions of their respective cyclic voltammograms.