Tracking and Therapeutic Value of Human Adipose Tissue–derived Mesenchymal Stem Cell Transplantation in Reducing Venous Neointimal Hyperplasia Associated with Arteriovenous Fistula | Zendy

Binxia Yang | Zendy; Akshaar Brahmbhatt | Zendy; Evelyn Nieves Torres | Zendy; Brian V. Thielen | Zendy; Deborah McCall | Zendy; Sean Engel | Zendy; Aditya Bansal | Zendy; Mukesh K. Pandey | Zendy; Allan B. Dietz | Zendy; Edward B. Leof | Zendy; Timothy R. DeGrado | Zendy; Debabrata Mukhopadhyay | Zendy; Sanjay Misra | Zendy

Open Access

Tracking and Therapeutic Value of Human Adipose Tissue–derived Mesenchymal Stem Cell Transplantation in Reducing Venous Neointimal Hyperplasia Associated with Arteriovenous Fistula

Author(s) -

Binxia Yang,

Akshaar Brahmbhatt,

Evelyn Nieves Torres,

Brian V. Thielen,

Deborah McCall,

Sean Engel,

Aditya Bansal,

Mukesh K. Pandey,

Allan B. Dietz,

Edward B. Leof,

Timothy R. DeGrado,

Debabrata Mukhopadhyay,

Sanjay Misra

Publication year - 2015

Publication title -

radiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.118

H-Index - 295

eISSN - 1527-1315

pISSN - 0033-8419

DOI - 10.1148/radiol.2015150947

Subject(s) - medicine , mesenchymal stem cell , neointimal hyperplasia , transplantation , adipose tissue , intimal hyperplasia , vein , pathology , adventitia , real time polymerase chain reaction , hyperplasia , urology , surgery , stent , restenosis , smooth muscle , biochemistry , chemistry , gene

To determine if adventitial transplantation of human adipose tissue-derived mesenchymal stem cells (MSCs) to the outflow vein of B6.Cg-Foxn1(nu)/J mice with arteriovenous fistula (AVF) at the time of creation would reduce monocyte chemoattractant protein-1 (Mcp-1) gene expression and venous neointimal hyperplasia. The second aim was to track transplanted zirconium 89 ((89)Zr)-labeled MSCs serially with positron emission tomography (PET) for 21 days.

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