Optimization of 7-T Chemical Exchange Saturation Transfer Parameters for Validation of Glycosaminoglycan and Amide Proton Transfer of Fibroglandular Breast Tissue | Zendy

Adrienne N. Dula | Zendy; Blake E. Dewey | Zendy; Lori R. Arlinghaus | Zendy; Jason M. Williams | Zendy; Dennis W. J. Klomp | Zendy; Thomas E. Yankeelov | Zendy; Seth A. Smith | Zendy

Open Access

Optimization of 7-T Chemical Exchange Saturation Transfer Parameters for Validation of Glycosaminoglycan and Amide Proton Transfer of Fibroglandular Breast Tissue

Author(s) -

Adrienne N. Dula,

Blake E. Dewey,

Lori R. Arlinghaus,

Jason M. Williams,

Dennis W. J. Klomp,

Thomas E. Yankeelov,

Seth A. Smith

Publication year - 2014

Publication title -

radiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.118

H-Index - 295

eISSN - 1527-1315

pISSN - 0033-8419

DOI - 10.1148/radiol.14140762

Subject(s) - intraclass correlation , confidence interval , medicine , nuclear magnetic resonance , nuclear medicine , magnetic resonance imaging , coefficient of variation , radiology , statistics , mathematics , physics , clinical psychology , psychometrics

To (a) implement simulation-optimized chemical exchange saturation transfer (CEST) measurements sensitive to amide proton transfer (APT) and glycosaminoglycan (GAG) hydroxyl proton transfer effects in the human breast at 7 T and (b) determine the reliability of these techniques for evaluation of fibroglandular tissue in the healthy breast as a benchmark for future studies of pathologic findings.

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