Open AccessOptimization of 7-T Chemical Exchange Saturation Transfer Parameters for Validation of Glycosaminoglycan and Amide Proton Transfer of Fibroglandular Breast Tissue
Author(s) -
Adrienne N. Dula,
Blake E. Dewey,
Lori R. Arlinghaus,
Jeffrey P. Williams,
Dennis W. J. Klomp,
Thomas E. Yankeelov,
Seth A. Smith
Publication year - 2015
Publication title -
radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.118
H-Index - 295
eISSN - 1527-1315
pISSN - 0033-8419
DOI - 10.1148/radiol.14140762
Subject(s) - intraclass correlation , confidence interval , medicine , nuclear magnetic resonance , nuclear medicine , magnetic resonance imaging , coefficient of variation , radiology , statistics , mathematics , physics , clinical psychology , psychometrics
To (a) implement simulation-optimized chemical exchange saturation transfer (CEST) measurements sensitive to amide proton transfer (APT) and glycosaminoglycan (GAG) hydroxyl proton transfer effects in the human breast at 7 T and (b) determine the reliability of these techniques for evaluation of fibroglandular tissue in the healthy breast as a benchmark for future studies of pathologic findings.