Open AccessRole of Tissue Factor in Venous Thrombosis
Author(s) -
David A. Manly,
Jeremiah Boles,
Nigel Mackman
Publication year - 2011
Publication title -
annual review of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.475
H-Index - 207
eISSN - 1545-1585
pISSN - 0066-4278
DOI - 10.1146/annurev-physiol-042210-121137
Subject(s) - tissue factor , medicine , thrombosis , hemostasis , venous thrombosis , coagulation , pathological , fibrin , immunology
Venous thromboembolism (VTE) is a leading cause of morbidity and mortality worldwide. However, the mechanisms by which clots are formed in the deep veins have not been determined. Tissue factor (TF) is the primary initiator of the coagulation cascade and is essential for hemostasis. Under pathological conditions, TF is released into the circulation on small-membrane vesicles termed microparticles (MPs). Recent studies suggest that elevated levels of MP TF may trigger thrombosis. This review provides an overview of the role of TF in VTE.