Open AccessNew Approaches to Glioblastoma
Author(s) -
Mustafa Khasraw,
Yöko Fujita,
Catalina Lee-Chang,
Irina V. Balyasnikova,
Hinda Najem,
Amy B. Heimberger
Publication year - 2022
Publication title -
annual review of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.03
H-Index - 160
eISSN - 1545-326X
pISSN - 0066-4219
DOI - 10.1146/annurev-med-042420-102102
Subject(s) - glioblastoma , prioritization , clinical trial , selection (genetic algorithm) , medicine , radiomics , intensive care medicine , computer science , cancer research , artificial intelligence , pathology , business , process management , radiology
Faced with unique immunobiology and marked heterogeneity, treatment strategies for glioblastoma require therapeutic approaches that diverge from conventional oncological strategies. The selection and prioritization of targeted and immunotherapeutic strategies will need to carefully consider these features and companion biomarkers developed alongside treatment strategies to identify the appropriate patient populations. Novel clinical trial strategies that interrogate the tumor microenvironment for drug penetration and target engagement will inform go/no-go later-stage clinical studies. Innovative trial designs and analyses are needed to move effective agents toward regulatory approvals more rapidly.