Open AccessThe Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
Author(s) -
Beckley K. Davis,
Haitao Wen,
Jenny P.-Y. Ting
Publication year - 2011
Publication title -
annual review of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 18.301
H-Index - 301
eISSN - 1545-3278
pISSN - 0732-0582
DOI - 10.1146/annurev-immunol-031210-101405
Subject(s) - inflammasome , biology , inflammation , caspase 1 , immunity , immunology , aim2 , pyrin domain , secretion , disease , immune system , medicine , biochemistry , pathology
Inflammasome activation leads to caspase-1 activation, which causes the maturation and secretion of pro-IL-1β and pro-IL-18 among other substrates. A subgroup of the NLR (nucleotide-binding domain, leucine-rich repeat containing) proteins are key mediators of the inflammasome. Studies of gene-deficient mice and cells have implicated NLR inflammasomes in a host of responses to a wide range of microbial pathogens, inflammatory diseases, cancer, and metabolic and autoimmune disorders. Determining exactly how the inflammasome is activated in these diseases and disease models remains a challenge. This review presents and integrates recent progress in the field.