Subnanometer-Resolution Frequency Modulation Atomic Force Microscopy in Liquid for Biological Applications | Zendy

Takeshi Fukuma | Zendy

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Subnanometer-Resolution Frequency Modulation Atomic Force Microscopy in Liquid for Biological Applications

Author(s) -

Takeshi Fukuma

Publication year - 2009

Publication title -

japanese journal of applied physics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.487

H-Index - 129

eISSN - 1347-4065

pISSN - 0021-4922

DOI - 10.1143/jjap.48.08ja01

Subject(s) - atomic force microscopy , resolution (logic) , lipid bilayer , nanotechnology , modulation (music) , frequency modulation , microscopy , chemistry , materials science , membrane , optics , physics , radio frequency , computer science , telecommunications , artificial intelligence , acoustics , biochemistry

The spatial resolution and force sensitivity of frequency modulation atomic force microscopy (FM-AFM) in liquid have been dramatically improved in the last a few years. It is now possible to image individual atoms and molecules at a solid/liquid interface with a subnanometerscale resolution and a piconewton-order loading force. This capability enabled the direct visualization of hydration layers and mobile ions on a lipid bilayer and β-strands constituting an amyloid fibril. These striking results highlighted the significant potential of FM-AFM in biological research. Here, I summarize the technological innovation that brought about this progress and review biological applications of FM-AFM in liquid. © 2009 The Japan Society of Applied Physics

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