Open AccessPotentiation of Lupus Activity by Granulocyte Colony-Stimulating Factor
Author(s) -
Tsz Ching Mok,
Lok Ping Ng,
Eva Tsz Fung Chui,
Ho Yin Chung
Publication year - 2021
Publication title -
journal of clinical rheumatology and immunology
Language(s) - English
Resource type - Journals
eISSN - 2661-3425
pISSN - 2661-3417
DOI - 10.1142/s2661341721720019
Subject(s) - granulocyte colony stimulating factor , lupus nephritis , systemic lupus erythematosus , neutropenia , medicine , immunology , granulocyte , cytokine , cyclic neutropenia , granulocyte colony stimulating factor receptor , disease , chemotherapy
Recombinant human granulocyte colony-stimulating factor (G-CSF) is commonly used to accelerate recovery of neutropenia in patients with marrow suppression. We hereby report a patient with systemic lupus erythematosus (SLE) who developed diffuse lupus nephritis and impending cytokine storm after G-CSF therapy. The exact mechanisms by which G-CSF leads to lupus flares remains enigmatic. Increased neutrophil apoptosis and release of cytokines have been postulated. The use of G-CSF in patients with autoimmune disease should be cautious.