Open AccessA Case of Wheat-Dependent Exercise Induced Anaphylaxis (WDEIA)
Author(s) -
Winnie Wan Yin Yeung,
HaeSim Park
Publication year - 2019
Publication title -
journal of clinical rheumatology and immunology
Language(s) - English
Resource type - Journals
eISSN - 2661-3425
pISSN - 2661-3417
DOI - 10.1142/s2661341719720039
Subject(s) - anaphylaxis , immunoglobulin e , gliadin , wheat allergy , medicine , immunology , omalizumab , monoclonal antibody , antibody , allergy , gluten , pathology
Wheat dependent exercised induced anaphylaxis (WDEIA) is common in Asian adult populations especially in northern China and Korea. A classical WDEIA case is presented with detailed histories, investigations and management plans. Serum specific IgE to omega-5 gliadin is critical for the diagnosis of WDEIA. Avoidance from wheat and exercise are the keys for prevention of anaphylaxis. Omalizumab, a monoclonal antibody against IgE, is reserved for cases with recurrent anaphylaxis and active physical activity status and it is an off-label treatment.