Open AccessHealthy Genetically Normal Live-Birth After Mosaic Chromosome 5 Embryo Transfer: A Case Report
Author(s) -
Tam M. Luu,
Nhung C. Nguyen,
Cassandra Tran,
Anh H Le,
Bao G. Huynh,
Tuong Vinh Ho
Publication year - 2021
Publication title -
fertility and reproduction
Language(s) - English
Resource type - Journals
eISSN - 2661-3182
pISSN - 2661-3174
DOI - 10.1142/s2661318221720014
Subject(s) - embryo , biology , embryo transfer , trisomy , zygote , andrology , genetics , chromosome , in vitro fertilisation , amniocentesis , fetus , pregnancy , prenatal diagnosis , embryogenesis , medicine , gene
Embryonic mosaicism is defined as two or more distinct cell lines within an embryo, which is originally developed from a zygote. Although the potential of mosaic embryos still remain unclear, recent reports have proved that mosaic embryo transfer can achieve healthy live-births. Up to now, there is no report of a live-birth having mosaic trisomy of full chromosome 5 following in-vitro fertilization (IVF). Our case is the first case proving that the transfer of medium-mosaicism embryo can result in a healthy live-birth. The couple are both carriers of balanced reciprocal translocations (46,XX,t(2;8)(p23;q24.3) and 46,XY,t(12;16)(q13.2;q23)). They had three IVF cycles combined with PGT-SR (Preimplantation Genetic Testing for Structural Rearrangement). A total of 18 blastocysts were biopsied and no euploid embryo was found. After the conselling, the patients chose to transfer a 40% mosaic trisomy chromosome 5 embryo. The follow-up pregnancy including prenatal diagnosis, amniocentesis and peripheral blood chromosome analysis of the newborn revealed no trisomy chromosome 5.