Open AccessTwo Successful Deliveries after 6 and 13 Years from 10 Oocytes Vitrified for Fertility Preservation in a Then 20-Year-Old Patient with PH-Positive Acute Lymphoid Leukemia
Author(s) -
Yusuke Nakamura,
Hiroyuki Hattori,
Yukiko Nakajo,
Noriyuki Okuyama,
Nobuya Aono,
Yuya Takeshige,
Sakamoto Eri,
Kanako Sato,
Momoe Ota,
Masae Koizumi,
Mayumi Toya,
Hideki Igarashi,
Tomoko Hashimoto,
Koichi Kyono
Publication year - 2020
Publication title -
fertility and reproduction
Language(s) - English
Resource type - Journals
eISSN - 2661-3182
pISSN - 2661-3174
DOI - 10.1142/s2661318220500140
Subject(s) - fertility preservation , oocyte cryopreservation , live birth , cryopreservation , medicine , fertility , vitrification , pregnancy , embryo cryopreservation , gynecology , andrology , obstetrics , embryo , biology , population , environmental health , genetics , microbiology and biotechnology
Oocyte vitrification is one of the methods for preserving fertility of cancer patients. In 2013, we reported a successful live birth using cryopreserved oocytes from a patient who contracted Ph-positive acute lymphoid leukemia at the retrieval age of 20. In this report, we described a second live birth from the same patient. The patient visited our clinic in November 2018 hoping to utilize vitrified oocytes cryopreserved in 2007. As a result, a day 3 single eight-cell stage embryo was transferred in a hormone replacement therapy cycle. She became pregnant and gave birth to a healthy girl (2,740 g) in September 2019. This is a case report of two live births from 10 matured oocytes that had been preserved for 12 years.