Open AccessPaternal Age Does Not Influence the Outcomes of Assisted Reproduction in Donor Oocyte Cycles
Author(s) -
G. Venkata Rao,
Saniya Laheri,
M Krishna Chaitanya
Publication year - 2020
Publication title -
fertility and reproduction
Language(s) - English
Resource type - Journals
eISSN - 2661-3182
pISSN - 2661-3174
DOI - 10.1142/s2661318220500073
Subject(s) - intracytoplasmic sperm injection , live birth , miscarriage , logistic regression , reproduction , human fertilization , pregnancy , medicine , gynecology , pregnancy rate , andrology , paternal age , sperm , obstetrics , biology , in vitro fertilisation , genetics , anatomy , offspring
Purpose: To study effect of paternal age on pregnancy outcomes of intracytoplasmic sperm injections (ICSI). Methods: The present study is a retrospective analysis of 153 ICSI cycles on donor oocytes. The effect of paternal age on fertilization rates, implantation rates, total pregnancy rates, number of miscarriages and live births were analyzed. Results: 1422 donor oocytes were injected with sperm from 153 men. Linear regression analysis revealed no association between paternal age (28-54 years) and fertilization rate. No association was found between the embryo quality and paternal age. Of the 359 embryos transferred, linear regression analysis revealed no association between paternal age and implantation rate. After correcting for maternal age, binary logistic regression analysis revealed no association between total pregnancy rates (B = 0.943, CI 0.861-1.033, P = 0.205), live birth rates (B = 1.018, CI 0.896-1.158, P = 0.562) and miscarriage rates (B = 0.944, CI 0.866-1.029, P = 0.193) and paternal age. Conclusion: Paternal age does not seem to influence outcomes in assisted reproduction.