Open AccessApplication of glucocorticoids in patients with novel coronavirus infection: From bench to bedside
Author(s) -
Linwei Lu,
Jianhua Huang,
Xin Deng,
Xianjun Sun,
Jingcheng Dong
Publication year - 2020
Publication title -
traditional medicine and modern medicine
Language(s) - English
Resource type - Journals
eISSN - 2575-9019
pISSN - 2575-9000
DOI - 10.1142/s257590002030009x
Subject(s) - covid-19 , mechanism (biology) , coronavirus , bench to bedside , medicine , intensive care medicine , disease , bioinformatics , virology , biology , infectious disease (medical specialty) , medical physics , philosophy , epistemology , outbreak
Glucocorticoids (GCs) have potential anti-inflammatory and immunosuppressive effects. There is plenty of controversy about the application of glucocorticoids in the treatment of coronavirus disease 2019 (COVID-19). This paper briefly summarizes the mechanism of glucocorticoids and their receptors and clinical applications in COVID-19. Through reviewing the current literature, our aim is to have a deeper understanding of the mechanism of GCs and their clinical applications, so as to find possible ways to enhance their efficacy and reduce drug resistance or side effects.