Open AccessThe effects and mechanisms of pomegranate in the prevention and treatment of metabolic syndrome
Author(s) -
Jie Xu,
Ke Cao,
Lin Zhao,
Zhihui Feng,
Zhizhong Dong,
Jianke Li,
Jiankang Liu
Publication year - 2020
Publication title -
traditional medicine and modern medicine
Language(s) - English
Resource type - Journals
eISSN - 2575-9019
pISSN - 2575-9000
DOI - 10.1142/s2575900020300064
Subject(s) - metabolic syndrome , ampk , glut4 , medicine , antioxidant , punica , disease , diabetes mellitus , traditional medicine , bioinformatics , pharmacology , insulin resistance , biology , endocrinology , biochemistry , protein kinase a , enzyme
Metabolic syndrome, such as obesity, diabetes and cardiovascular disease, is becoming epidemic both in developing and developed countries in recent years. Vegetable and fruit consumptions have been associated with the prevention of metabolic syndrome. Pomegranate is a widely consumed fruit in Middle East and Asia. Currently, accumulating data showed that pomegranate exhibits antioxidant, anti-inflammatory, hypolipidemic and hypoglycemic activities in experimental and clinical studies. The beneficial effects of pomegranate may come from its rich polyphenols and be mediated by increasing the activity of AMPK, upregulating GLUT4, activating PPAR[Formula: see text]- ABCA1/CYP7A1 pathways and improving mitochondrial function. This review provides a systematical presentation of findings on the beneficial effects as well as the possible mechanisms of pomegranate and its major components on prevention and treatment of metabolic syndrome.