z-logo
open-access-imgOpen Access
How to choose the suitable animal model of polycystic ovary syndrome?
Author(s) -
Amin Tamadon,
Wei Hu,
Peng Cui,
Tong Ma,
Xiaoyu Tong,
Feifei Zhang,
Xin Li,
Ruijin Shao,
Yi Feng
Publication year - 2018
Publication title -
traditional medicine and modern medicine
Language(s) - English
Resource type - Journals
eISSN - 2575-9019
pISSN - 2575-9000
DOI - 10.1142/s2575900018300047
Subject(s) - polycystic ovary , animal model , etiology , androgen , letrozole , testosterone (patch) , bioinformatics , biology , medicine , physiology , endocrinology , hormone , insulin , aromatase , insulin resistance , cancer , breast cancer
Polycystic ovary syndrome (PCOS) is a gynecological metabolic and endocrine disorder with uncertain etiology. To understand the etiology of PCOS or the evaluation of various therapeutic agents, different animal models have been introduced. Considering this fact that is difficult to develop an animal model that mimics all aspects of this syndrome, but, similarity of biological, anatomical, and/or biochemical features of animal model to the human PCOS phenotypes can increase its application. This review paper evaluates the recently researched animal models and introduced the best models for different research purposes in PCOS studies. During January 2013 to January 2017, 162 studies were identified which applied various kinds of animal models of PCOS including rodent, primate, ruminant and fish. Between these models, prenatal and pre-pubertal androgen rat models and then prenatal androgen mouse model have been studied in detail than others. The comparison of main features of these models with women PCOS demonstrates higher similarity of these three models to human conditions. Thereafter, letrozole models can be recommended for the investigation of various aspects of PCOS. Interestingly, similarity of PCOS features of post-pubertal insulin and human chorionic gonadotropin rat models with women PCOS were considerable which can make it as a good choice for future investigations.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here