Open AccessFlexible organic–inorganic hybrid bioceramic for bone tissue regeneration
Author(s) -
Jing Chen,
Xingmei Zhang,
Beibei Li,
Yawei Yang
Publication year - 2020
Publication title -
journal of advanced dielectrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.38
H-Index - 13
eISSN - 2010-135X
pISSN - 2010-1368
DOI - 10.1142/s2010135x20500137
Subject(s) - bioceramic , biocompatibility , biomineralization , materials science , simulated body fluid , bone tissue , osteoblast , chemical engineering , biomedical engineering , regeneration (biology) , nanotechnology , composite material , in vitro , chemistry , scanning electron microscope , metallurgy , biochemistry , medicine , microbiology and biotechnology , engineering , biology
Development of novel biomaterials for bone regeneration is based on the sufficient bone-bonding ability, bioactivity and biocompatibility. In this study, novel flexible poly(butylene succinate)/polydimethysiloxane-modified bioactive glass/nano-hydroxyapatite (PBSu/PDMS-BG/nHA) hybrid bioceramic with various nHA concentration on the in vitro bone-like hydroxyapatite (HA) formation, biomineralization activity and osteoblast cell biocompatibility were investigated. The rapid precipitation of HA on the hybrid bioceramic surfaces was found after being immersed in simulated body fluid (SBF) for seven days. Results show that the amount of HA deposition increased with the increase of nHA concentration. The optimized PBSu/PDMS-BG/nHA hybrid bioceramic exhibited good flexibility, high biomineralization activity and good osteoblast cell biocompatibility.