Open AccessHigh-speed all-optic optical coherence tomography and photoacoustic microscopy dual-modal system for microcirculation evaluation
Author(s) -
Yang Lin,
Menghan Yu,
Yi Wang,
Ziyue Meng,
Ang Li,
Zuyuan He,
Qiaoyun Wang,
Jian Liu,
Yao Yu,
Yuqian Zhao,
Xin Zhu,
Zhenhe Ma
Publication year - 2022
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545822500237
Subject(s) - optical coherence tomography , interferometry , optics , sensitivity (control systems) , photoacoustic doppler effect , physics , materials science , acoustics , computer science , biomedical engineering , photoacoustic imaging in biomedicine , engineering , electronic engineering
We propose a high-speed all-optic dual-modal system that integrates spectral-domain optical coherence tomography and photoacoustic microscopy (PAM). A [Formula: see text] coupler-based interferometer is used to remotely detect the surface vibration caused by photoacoustic (PA) waves. Three outputs of the interferometer are acquired simultaneously with a multi-channel data acquisition card. One channel data with the highest PA signal detection sensitivity is selected for sensitivity compensation. Experiment on the phantom demonstrates that the proposed method can successfully compensate for the loss of intensity caused by sensitivity variation. The imaging speed of the PAM is improved compared to our previous system. The total time to image a sample with [Formula: see text] pixels is [Formula: see text][Formula: see text]s. Using the proposed system, the microvasculature in the mouse auricle is visualized and the blood flow state is accessed.