Open AccessOrthogonal Aza-BODIPY–BODIPY dyad as heavy-atom free photosensitizer for photo-initiated antibacterial therapy
Author(s) -
Dongliang Yang,
Liguo Sun,
Lei Xue,
Xiaorui Wang,
Yanling Hu,
Jinjun Shao,
Ling Fu,
Xiaochen Dong
Publication year - 2021
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545822500043
Subject(s) - photosensitizer , bodipy , photodynamic therapy , photochemistry , photothermal therapy , biocompatibility , fluorescence , reactive oxygen species , chemistry , irradiation , materials science , nanotechnology , organic chemistry , optics , biochemistry , physics , nuclear physics
Photodynamic antibacterial therapy shows great potential in bacterial infection and the reactive oxygen species (ROS) production of the photosensitizers is crucial for the therapeutic effect. Introducing heavy atoms is a common strategy to enhance photodynamic performance, while dark toxicity can be induced to impede further clinical application. Herein, a novel halogen-free photosensitizer Aza-BODIPY-BODIPY dyad NDB with an orthogonal molecular configuration was synthesized for photodynamic antibacterial therapy. The absorption and emission peaks of NDB photosensitizer in toluene were observed at 703[Formula: see text]nm and 744[Formula: see text]nm, respectively. The fluorescence (FL) lifetime was measured to be 2.8[Formula: see text]ns in toluene. Under 730 nm laser illumination, the ROS generation capability of NDB was 3-fold higher than that of the commercial ICG. After nanoprecipitation, NDB NPs presented the advantages of high photothermal conversion efficiency (39.1%), good photostability, and excellent biocompatibility. More importantly, in vitro antibacterial assay confirmed that the ROS and the heat generated by NDB NPs could extirpate methicillin-resistant S. aureus effectively upon exposure to 730[Formula: see text]nm laser, suggesting the potential application of NDB NPs in photo-initiated antibacterial therapy.