Open AccessLaser speckle contrast imaging for monitoring of acute pancreatitis at ischemia–reperfusion injury of the pancreas in rats
Author(s) -
Polina A. Dyachenko,
Alexey N. Bashkatov,
D. A. Alexandrov,
Vyacheslav I. Kochubey,
Valery V. Tuchin
Publication year - 2021
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545822420020
Subject(s) - speckle pattern , microcirculation , blood flow , medicine , ischemia , acute pancreatitis , pancreatitis , pancreas , in vivo , cardiology , radiology , pathology , physics , biology , optics , microbiology and biotechnology
The influence of ischemia–reperfusion (I/R) action on pancreatic blood flow (PBF) and the development of acute pancreatitis (AP) in laboratory rats is evaluated in vivo by using the laser speckle contrast imaging (LSCI). Additionally, the optical properties in norm and under condition of AP in rats were assessed using a modified integrating sphere spectrometer and inverse Monte Carlo (IMC) software. The results of the experimental study of microcirculation of the pancreas in 82 rats in the ischemic model are presented. The data obtained confirm the fact that local ischemia and changes in the blood flow velocity of the main vessels cause and provoke acute pancreatitis.