Open AccessCorneal damage effects induced by infrared optical parametric oscillator radiation at 3743 nm
Author(s) -
Lei Jiao,
Chao Wang,
Kaizeng Zhang,
Jiarui Wang,
Zaifu Yang
Publication year - 2020
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545821500048
Subject(s) - corneal epithelium , exposure duration , radiation , optical parametric oscillator , wavelength , physics , chemistry , optics , cornea , toxicology , biology
The main aim of this paper is to investigate the corneal damage effects induced by mid-infrared optical parametric oscillator (OPO) radiation. Experiments were performed to determine the corneal damage thresholds of New Zealand white rabbit at the wavelength of 3743[Formula: see text]nm for exposure durations of 0.1[Formula: see text]s, 1.0[Formula: see text]s and 10.0[Formula: see text]s. Through slit-lamp biomicroscope and histopathology, corneal injury characteristics were revealed. The damage thresholds were 3.73[Formula: see text]J/cm 2 , 7.91[Formula: see text]J/cm 2 and 31.1[Formula: see text]J/cm 2 , respectively, for exposure durations of 0.1[Formula: see text]s, 1.0[Formula: see text]s and 10.0[Formula: see text]s. The damage data was correlated by an empirical equation: Radiant exposure at the [Formula: see text] duration,[Formula: see text] where the units of radiant exposure and exposure duration were J/cm 2 and second. At near-threshold level, corneal injuries at 1 h post-exposure mainly involved the epithelium, and the epithelium damages repaired at 24-h post-exposure. There are sufficient safety margins between the damage thresholds and the maximum permitted exposures from current international laser safety standard IEC 60825-1.