Open AccessCytochrome-c aptamer functionalized Pt nanoclusters for enhanced chemodynamic therapy
Author(s) -
Bo Feng,
Dan Zhao,
Yaowei Peng,
Fu Wang
Publication year - 2021
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545821410042
Subject(s) - nanoclusters , hydrogen peroxide , aptamer , chemistry , biosafety , catalysis , cancer cell , combinatorial chemistry , reactive oxygen species , hydroxyl radical , cancer therapy , cytochrome c , radical , mitochondrion , biophysics , biochemistry , cancer , microbiology and biotechnology , biology , organic chemistry , genetics
Catalysis-based chemodynamic therapy (CDT) is an emerging cancer treatment strategy which uses a Fenton-like reaction to kill tumor cells by catalyzing endogenous hydrogen peroxide (H 2 O[Formula: see text] into a toxic hydroxyl radical ([Formula: see text]OH). The performance of CDT is greatly dependent on PDT agent. Herein, mitochondria-targeting Pt nanoclusters were synthesized using cytochrome c aptamer (CytcApt) as template. The obtained CytcApt-PtNCs can produce [Formula: see text]OH by H 2 O 2 under the acidic conditions. Moreover, CytcApt-PtNCs could kill 4T1 tumor cells in a pH-dependent manner, but had no side effect on normal 293T cells. Therefore, CytcApt-PtNCs possess excellent therapeutic effect and good biosafety, indicating their great potential for CDT.