Construction of Au@Metal-organic framework for sensitive determination of creatinine in urine | Zendy

Yuning Jiang | Zendy; Yanzheng Cai | Zendy; Sen Hu | Zendy; Xiaoyu Guo | Zendy; Ye Ying | Zendy; Ying Wen | Zendy; Yiping Wu | Zendy; Haifeng Yang | Zendy

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Construction of Au@Metal-organic framework for sensitive determination of creatinine in urine

Author(s) -

Yuning Jiang,

Yanzheng Cai,

Sen Hu,

Xiaoyu Guo,

Ye Ying,

Ying Wen,

Yiping Wu,

Haifeng Yang

Publication year - 2021

Publication title -

journal of innovative optical health sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.421

H-Index - 24

eISSN - 1793-5458

pISSN - 1793-7205

DOI - 10.1142/s1793545821410030

Subject(s) - urine , renal function , creatinine , detection limit , substrate (aquarium) , chemistry , surface plasmon resonance , nanoparticle , materials science , chromatography , nanotechnology , biochemistry , geology , oceanography

Creatinine level in urine is an important biomarker for renal function diseases, such as renal failure, glomerulonephritis, and chronic nephritis. The Au@MIL-101(Fe) was prepared by in situ growth of Au nanoparticles in MIL-101(Fe) as a selective SERS substrate. The Au@MIL-101(Fe) offers the great local surface plasmon resonance (SPR) effect due to gold nanoparticles aggregation inside metal-organic frameworks. The framework structure could enrich trace target samples and drag them into SPR hot spots. The optimal Au@MIL-101(Fe) composite substrate is used for analyzing creatinine in urine and the limit of detection is down to 0.1[Formula: see text][Formula: see text]mol/L and a linear relationship is ranging from 1[Formula: see text][Formula: see text]mol/L to 100[Formula: see text][Formula: see text]mol/L.

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