Open AccessConstruction of Au@Metal-organic framework for sensitive determination of creatinine in urine
Author(s) -
Yuning Jiang,
Yanzheng Cai,
Sen Hu,
Xiaoyu Guo,
Ying Ye,
Ying Wen,
Yiping Wu,
Haifeng Yang
Publication year - 2021
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545821410030
Subject(s) - urine , renal function , creatinine , detection limit , substrate (aquarium) , chemistry , surface plasmon resonance , nanoparticle , materials science , chromatography , nanotechnology , biochemistry , geology , oceanography
Creatinine level in urine is an important biomarker for renal function diseases, such as renal failure, glomerulonephritis, and chronic nephritis. The Au@MIL-101(Fe) was prepared by in situ growth of Au nanoparticles in MIL-101(Fe) as a selective SERS substrate. The Au@MIL-101(Fe) offers the great local surface plasmon resonance (SPR) effect due to gold nanoparticles aggregation inside metal-organic frameworks. The framework structure could enrich trace target samples and drag them into SPR hot spots. The optimal Au@MIL-101(Fe) composite substrate is used for analyzing creatinine in urine and the limit of detection is down to 0.1[Formula: see text][Formula: see text]mol/L and a linear relationship is ranging from 1[Formula: see text][Formula: see text]mol/L to 100[Formula: see text][Formula: see text]mol/L.