Open AccessOptically-excited simultaneous photoacoustic and ultrasound imaging based on a flexible gold-PDMS film
Author(s) -
Dandan Cui,
Zhenhui Zhang,
Yujiao Shi
Publication year - 2020
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545820500121
Subject(s) - materials science , polydimethylsiloxane , laser , photoacoustic effect , optics , transmittance , ultrasound , colloidal gold , optoelectronics , photoacoustic imaging in biomedicine , finite element method , thermoelastic damping , signal (programming language) , nanoparticle , nanotechnology , acoustics , physics , thermal , meteorology , computer science , thermodynamics , programming language
We constructed a flexible gold-polydimethylsiloxane (gold-PDMS) nanocomposites film with controllable thickness and light transmittance, to realize optically-excited simultaneous photoacoustic (PA) and ultrasound (US) imaging under a single laser pulse irradiation. Benefiting from the excellent thermoelastic properties, the gold-PDMS film absorbs part of the incident laser energy and produces a high-intensity US, which is used to realize US imaging. Meanwhile, the partly transmitted light is used to excite samples for PA imaging. By controlling the thickness of the gold-PDMS, we can control the center frequency in the US imaging. We experimentally analyzed the frequency of the produced US signal by the gold-PDMS film and compared it with the finite element analysis (FEA) method, where the experiments agree with the FEA results. This method is demonstrated by the experiments on phantoms and a mouse model. Our work provides a cost-effective methodology for simultaneous PA and US imaging.