Open AccessRelease characteristics of different diameter ultrafine fibers as antibacterial materials
Author(s) -
Zhiqiang Wei,
Erniao Liu,
Hao Li,
Zhimei Wei,
Zhi Lv
Publication year - 2021
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545820410059
Subject(s) - electrospinning , materials science , antimicrobial , biocompatibility , fiber , composite material , antibacterial activity , nanotechnology , chemistry , polymer , bacteria , metallurgy , organic chemistry , biology , genetics
Although the electrospinning technique has been devoted to promoting therapeutic purposes as a drug carrier, however, there are still many fundamental problems in this area. This work focuses on a comparison of various diameter polyethersulfone (PES) electrospun ultrafine fibers as antimicrobial materials. The fibrous morphology, antimicrobial agent distribution, thermally property, and biocompatibility evaluation of PES-based ultrafine fibers were systematically investigated. The results demonstrated that the PES-based ultrafine fibers were suitable as antimicrobial material. Furthermore, the drug release behavior and mechanism were studied through total immersion. The release mechanism was confirmed to Fickian diffusion. It was revealed that the drug max release amount (71.5%) and release rate (7.71) are the highest for the smallest diameter ultrafine fibers. Meanwhile, the antimicrobial activity of PES ultrafine fibers is also inversely correlated with the diameter of fiber. The electrospun PES fibers would control their release behavior through the diameter and have a potential application in the wound dressings, such as chronic osteomyelitis and exposure injury.