Open AccessThree-dimensional imaging of spatio-temporal dynamics of small blood capillary network in the cortex based on optical coherence tomography: A review
Author(s) -
Fangjian Xing,
Jang-Hoon Lee,
Collin Polucha
Publication year - 2019
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545820300025
Subject(s) - optical coherence tomography angiography , blood flow , optical coherence tomography , coherence (philosophical gambling strategy) , neuroimaging , capillary action , biomedical engineering , optics , angiography , cortex (anatomy) , physics , neuroscience , computer science , medicine , radiology , psychology , quantum mechanics , thermodynamics
Optical coherence tomography angiography (OCTA) has emerged as an advanced in vivo imaging modality, which is widely used for the clinic ophthalmology and neuroscience research in the rodent brain cortex among others. Based on the high numerical aperture (NA) probing lens and the motion-corrected algorithms, a high-resolution imaging technique called OCT micro-angiography is applied to resolve the small blood capillary vessels ranging from 5[Formula: see text][Formula: see text]m to 10[Formula: see text][Formula: see text]m in diameter. As OCT-based techniques are recently evolving further from the structural imaging of capillaries toward spatio-temporal dynamic imaging of blood flow in capillaries, here we present a review on the latest techniques for the dynamic flow imaging. Studies on capillary blood flow using these techniques will help us better understand the roles of capillary blood flow for normal functioning of the brain as well as how it malfunctions in diseases.