Open AccessObservation of the early blood vessels of cutaneous malignant melanoma using Swept Source Optical Coherence Tomography Angiography (SS-OCTA)
Author(s) -
Jingxuan Liu,
Jun Fan,
Quan Wang,
Wen He,
Caihua Dong,
Minxuan Sun,
Guohua Shi
Publication year - 2019
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545819420057
Subject(s) - medicine , angiography , melanoma , optical coherence tomography , biopsy , radiology , blood vessel , tomography , pathology , angiogenesis , conventional angiography , vascular network , nuclear medicine , anatomy , cancer research
Melanoma, characterized by high mortality, rapid development and accompanied with angiogenesis is the most typical malignant tumor in skin cancer. Hence, the detection of blood vessels is of much significance. The early vascular network has small scale. If we remove the tumor early and biopsy it, it will increase the spread of the cancer cells and infection and bleeding. In this case, we presented a new angiography method. A high-resolution OCT system for noninvasive angiographic imaging of early skin melanoma — Swept Source Optical Coherence Tomography Angiography (SS-OCTA) is proposed. With a high lateral resolution of 10[Formula: see text][Formula: see text]m in vivo tomographic angiography, SS-OCTA is used to image and identify the morphology of the early tumor blood vessels. In addition, a control group experiment is conducted to observe the growth of melanoma in the process of rupture, malformation of micro-vessels. The results of the analysis and statistical test ([Formula: see text]) are statistically significant.