Open AccessAnti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo
Author(s) -
Lijun Zhang,
Laixing Wang,
Weili Zhang,
Yuan Yan,
Zhilong Chen
Publication year - 2015
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545815400039
Subject(s) - chlorin , photodynamic therapy , photosensitizer , in vivo , singlet oxygen , in vitro , irradiation , chemistry , laser , photochemistry , cancer research , medicine , oxygen , optics , biology , physics , biochemistry , microbiology and biotechnology , organic chemistry , nuclear physics
In this study, a novel photosensitizer meso-tetra (3-pyrrolidinomethyl-4-methoxyphenyl) chlorin (TPMC) was reported. It displays a characteristic long wavelength absorption peak at 656 nm and it shows a singlet oxygen quantum yield of 0.48. After light irradiation with 650 nm laser, it can kill Eca-109 and SMMC-7721 cells in vitro (25 mW/cm2, 1.2 to 3.6 J/cm2) and destroy Eca-109 tumor in nude mice (50 mW/cm2, 90 J/cm2). It has the perspective to be developed as a new anti-tumor drug in photodynamic therapy (PDT) photodiagnosis, and deserves further investigation