Open AccessEarly identification of acute hypoxia based on brain NADH fluorescence and cerebral blood flow
Author(s) -
Hua Shi,
Nannan Sun,
Avraham Mayevsky,
Zhihong Zhang,
Qingming Luo
Publication year - 2014
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545814500333
Subject(s) - hypoxia (environmental) , cerebral blood flow , nicotinamide adenine dinucleotide , medicine , respiration , blood flow , cardiology , biology , biochemistry , pathology , chemistry , nad+ kinase , oxygen , enzyme , anatomy , organic chemistry
Hypoxia is closely related to many diseases and often leads to death. Early detection and identification of the hypoxia causes may help to promptly determine the right rescue plan and reduce the mortality. We proposed a new multiparametric monitoring method employing mitochondrial reduced nicotinamide adenine dinucleotide (NADH) fluorescence, regional reflectance, regional cerebral blood flow (CBF), electrocardiography (ECG), and respiration under six kinds of acute hypoxia in four categories to investigate a correlation between the parameter variances and the hypoxia causes. The variation patterns of the parameters were discussed, and the combination of NADH and CBF may contribute to the identification of the causes of hypoxia