Open AccessMacrophage as cellular vehicles for delivery of nanoparticles
Author(s) -
Song Feng,
Sisi Cui,
Jing Jin,
Yueqing Gu
Publication year - 2014
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545814500230
Subject(s) - macrophage , drug delivery , blood–brain barrier , internalization , targeted drug delivery , confocal microscopy , penetration (warfare) , chemistry , in vitro , confocal , receptor , biophysics , microbiology and biotechnology , central nervous system , biology , neuroscience , biochemistry , geometry , mathematics , organic chemistry , operations research , engineering
Treatment of malignant brain tumors continues to challenge scientists and clinicians alike. Location of these tumors within the central nervous system (CNS), which is considered a "privileged" organ, can prevent the penetration of chemotherapeutic agents through the blood–brain barrier (BBB). To overcome this limitation, nanoparticles are taken up and transported by macrophage and then delivered directly into the CNS. In this study, we used macrophage to uptake the folate-targeted bifunctional micelles loaded with near-infrared (NIR) dye ICG-Der-01 and investigate the dynamic bio-distributions of macrophage after intravenous injection into tumor-bearing mice. In vitro cellular experiments by confocal microscopy indicated that the uptake of micelles in macrophage was greatly enhanced due to the folate receptor overexpression. Dynamic bio-distributions of macrophage showed a rapid clearing rate through the liver intestine pathway. In conclusion, macrophage could potentially be used as nanoparticle drug carriers and require further investigation