Open AccessHYALURONAN IN THE CEREBROSPINAL FLUID OF PATIENTS WITH SPINAL TUMOR
Author(s) -
Kenshi Sakayama,
Teruki Kidani,
Hiroyuki Tsuchiya,
Nozomu Tanji,
Yuji Watanabe,
Haruyasu Yamamoto,
Yoshifumi Sugawara
Publication year - 2006
Publication title -
journal of musculoskeletal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.12
H-Index - 15
eISSN - 1793-6497
pISSN - 0218-9577
DOI - 10.1142/s0218957706001819
Subject(s) - cerebrospinal fluid , medicine , myelography , intramedullary rod , pathology , hyaluronic acid , csf albumin , cerebral spinal fluid , surgery , spinal cord , anesthesia , anatomy , psychiatry
The clinical significance of hyaluronan (HA) levels in the cerebrospinal fluid (CSF) of patients with spinal tumor (ST) was evaluated in order to clarify whether HA concentrations in the CSF of patients with ST differ according to such factors as the tumor site and histopathological diagnosis. CSF samples were obtained from 40 patients with ST who had undergone myelography and CSF examinations retrospectively. The HA levels were determined using a sandwich-binding protein assay. The total protein (TP) levels were also determined. The HA and TP concentrations in CSF were significantly higher in patients with extramedullary tumor than in patients with intramedullary tumor. There was a significant correlation between HA and TP concentrations in CSF patients with ST. A HA assay for CSF is therefore considered to be potentially useful for estimating the localization of ST. © 2006 World Scientific Publishing Company
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom