Open AccessAngelica dahurica and Rheum officinale Facilitated Diabetic Wound Healing by Elevating Vascular Endothelial Growth Factor
Author(s) -
Yuh-Huey Chao,
Wanting Yang,
Mingchang Li,
Fwu-Lin Yang,
RuPing Lee
Publication year - 2021
Publication title -
the american journal of chinese medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 63
eISSN - 1793-6853
pISSN - 0192-415X
DOI - 10.1142/s0192415x21500713
Subject(s) - wound healing , medicine , saline , streptozotocin , diabetes mellitus , vascular endothelial growth factor , intraperitoneal injection , nitric oxide synthase , nitric oxide , traditional medicine , endocrinology , pharmacology , vegf receptors , surgery
Traditional Chinese medicine (TCM) provides alternative treatment choices for diabetic wounds. The aim of this study was to evaluate the effects of Angelica dahurica and Rheum officinale (ARE) on diabetic wounds and its underlying action mechanism. A total of 36 healthy male Sprague–Dawley rats were randomly divided into three groups: diabetes mellitus (DM) rats treated with ARE (DM-ARE), DM rats treated with 0.9% saline (DM-NS), and non-DM rats treated with 0.9% saline (NDM-NS). DM was induced by intraperitoneal administration of 40 mg/kg of streptozotocin after a 2-week high-fat diet feeding. After excisional skin wounds and treatments, the remaining wound area (RWA) in each group was measured. The RWA in the DM-NS group (69.60% ± 2.35%) was greater than that in the DM-ARE (55.70% ± 1.85%) and NDM-NS groups (52.50% ± 2.77%) on day 6. Besides, the DM-ARE group showed higher vascular endothelial growth factor (VEGF), higher inducible nitric oxide synthase (iNOs), higher [Formula: see text]-smooth muscle actin ([Formula: see text]-SMA), and lower nuclear factor kappa-light-chain-enhancer of activated B cell (NF-[Formula: see text]B) expression in the wound skin tissue. These results showed that treatment with ARE shifted the recovery pattern of diabetic rats to the pattern of nondiabetic rats, indicating that ARE may improve wound healing in diabetic conditions.