Peripheral expression of inflammatory markers in overweight female adolescents and eutrophic female adolescents with a high percentage of body fat | Zendy

Gisele Queiroz Carvalho | Zendy; Patrícia Feliciano Pereira | Zendy; Hiara Miguel Stancioli Serrano | Zendy; Sylvia do Carmo Castro Franceschini | Zendy; Sérgio Oliveira de Paula | Zendy; Sílvia Eloíza Priore | Zendy; Maria do Carmo Gouveia Pelúzio | Zendy

Open Access

Peripheral expression of inflammatory markers in overweight female adolescents and eutrophic female adolescents with a high percentage of body fat

Author(s) -

Gisele Queiroz Carvalho,

Patrícia Feliciano Pereira,

Hiara Miguel Stancioli Serrano,

Sylvia do Carmo Castro Franceschini,

Sérgio Oliveira de Paula,

Sílvia Eloíza Priore,

Maria do Carmo Gouveia Pelúzio

Publication year - 2010

Publication title -

applied physiology nutrition and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.789

H-Index - 89

eISSN - 1715-5320

pISSN - 1715-5312

DOI - 10.1139/h10-033

Subject(s) - overweight , proinflammatory cytokine , peripheral , medicine , endocrinology , metabolic syndrome , obesity , interleukin 6 , insulin resistance , tumor necrosis factor alpha , correlation , positive correlation , peripheral blood , inflammation , geometry , mathematics

The objective of this study was to evaluate the peripheral expression of inflammatory markers in adolescents with different nutritional status and its correlation with parameters of the metabolic syndrome. Seventy-two female postpubescent adolescents were divided into 3 groups: eutrophic (Co), eutrophic with a high body fat percentage (HBF), and overweight (OW). Data related to the parameters of the metabolic syndrome and the peripheral expression of tumour necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10 were evaluated. Higher values of glycemia and insulin resistance were found in the HBF group than in the Co group. No differences related to the peripheral expression of the cytokines were found among the groups. In the HBF group, a positive correlation was observed between TNF-α and IL-6, IL-10 and the proinflammatory cytokines, and IL-6 and glycemia. In the OW group, a positive correlation was found between IL-6 and triglycerides. Adolescents with normal weight but body fat excess present a metabolic profile and body composition similar to those of overweight adolescents. This suggests that these adolescents have a risk of developing cardiovascular diseases similar to that of overweight adolescents. The positive correlation between IL-10 and TNF-α and IL-6 suggests an attempt to inhibit the production of these cytokines by IL-10.

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