Vascular and renal telomere shortening in mice exposed to chronic intermittent hypoxia | Zendy

Mohammad Badran | Zendy; Bisher Abuyassin | Zendy; Najib Ayas | Zendy; Don D. Sin | Zendy; Ismail Laher | Zendy

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Vascular and renal telomere shortening in mice exposed to chronic intermittent hypoxia

Author(s) -

Mohammad Badran,

Bisher Abuyassin,

Najib Ayas,

Don D. Sin,

Ismail Laher

Publication year - 2021

Publication title -

canadian journal of physiology and pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.559

H-Index - 84

eISSN - 1205-7541

pISSN - 0008-4212

DOI - 10.1139/cjpp-2021-0143

Subject(s) - telomere , medicine , intermittent hypoxia , obstructive sleep apnea , kidney disease , hypoxia (environmental) , endocrinology , senescence , kidney , sleep apnea , cardiology , pathology , biology , chemistry , dna , genetics , organic chemistry , oxygen

Obstructive sleep apnea (OSA) is a chronic condition characterized by chronic intermittent hypoxia (IH) and is associated with cardiovascular (CVD) and chronic kidney diseases (CKD). Patients with OSA have increased biomarkers of aging such as telomere shortening. We used PCR to report shortened telomere lengths in aortic and renal tissues from mice exposed to 8 weeks of IH. Our data indicate that IH, a hallmark of OSA, accelerates vascular and renal aging that may contribute to OSA-induced CVD and CKD.

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