The acute effects of different spironolactone doses on cardiac function in streptozotocin-induced diabetic rats | Zendy

Aleksandra Vranić | Zendy; Stefan Simović | Zendy; Petar Ristić | Zendy; Tamara Nikolić | Zendy; Isidora Stojić | Zendy; Ivan Srejović | Zendy; Vladimir Živković | Zendy; Vladimir Jakovljević | Zendy; Dušan Djurić | Zendy

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The acute effects of different spironolactone doses on cardiac function in streptozotocin-induced diabetic rats

Author(s) -

Aleksandra Vranić,

Stefan Simović,

Petar Ristić,

Tamara Nikolić,

Isidora Stojić,

Ivan Srejović,

Vladimir Živković,

Vladimir Jakovljević,

Dušan Djurić

Publication year - 2017

Publication title -

canadian journal of physiology and pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.559

H-Index - 84

eISSN - 1205-7541

pISSN - 0008-4212

DOI - 10.1139/cjpp-2017-0055

Subject(s) - spironolactone , medicine , diabetes mellitus , streptozotocin , endocrinology , mineralocorticoid receptor , cardiac function curve , mineralocorticoid , heart failure , aldosterone

Currently, cardiovascular diseases are the leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity. A recent study showed that patients with diabetes mellitus treated with mineralocorticoid receptor antagonists have improved coronary microvascular function, leading to improved diastolic dysfunction. In this study, we evaluated the influence of acute administration of spironolactone on myocardial function in rats with streptozotocin-induced diabetes mellitus, with special emphasis on cardiodynamic parameters in diabetic rat hearts. The present study was carried out on 40 adult male Wistar albino rats (8 weeks old). Rats were randomly divided into 4 groups (10 animals per group): healthy rats treated with 0.1 μmol/L of spironolactone, diabetic rats treated with 0.1 μmol/L of spironolactone, healthy rats treated with 3 μmol/L of spironolactone, and diabetic rats treated with 3 μmol/L of spironolactone. Different, dose-dependent, acute responses of spironolactone treatment on isolated, working diabetic and healthy rat heart were observed in our study. In healthy rats, better systolic function was achieved with higher spironolactone dose, while in diabetic rats, similar effects of low and high spironolactone dose were observed.

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