Open AccessMetabolic flexibility during late pregnancy is associated with neonatal adiposity
Author(s) -
Rachel A. Tinius,
Maire M. Blankenship,
Karen Furgal,
W. Todd Cade,
Cathryn Duchette,
Kevin J. Pearson,
Jill M. Maples
Publication year - 2021
Publication title -
applied physiology, nutrition and metabolism/applied physiology, nutrition, and metabolism
Language(s) - English
Resource type - Journals
eISSN - 1715-5320
pISSN - 1715-5312
DOI - 10.1139/apnm-2020-1005
Subject(s) - body mass index , medicine , insulin resistance , pregnancy , anthropometry , endocrinology , flexibility (engineering) , obstetrics , obesity , biology , mathematics , statistics , genetics
The aim of this study was to determine the relationships between maternal metabolic flexibility during pregnancy and neonatal health outcomes. Percent change in lipid oxidation (before and after a high-fat meal) was calculated as the measure of "metabolic flexibility". Neonatal adiposity was assessed within 48 h of delivery by skinfold anthropometry. Metabolic flexibility ( r = -0.271, p = 0.034), maternal HOMA-IR ( r = 0.280, p = 0.030), and maternal body mass index ( r = 0.299, p = 0.018) were correlated with neonatal subscapular skinfold (i.e., measure of neonatal adiposity). Clinical Trail Registration Number: NCT03504319. Novelty: This is the first study to link maternal metabolic flexibility, body mass index, and insulin resistance during pregnancy to neonatal adiposity at parturition.