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Effects of short‐term oral administration of trimethoprim‐sulfamethoxazole on Schirmer II tear test results in clinically normal rabbits
Author(s) -
Shirani D.,
Selk Ghaffari M.,
Akbarein H.,
Haji Ali Asgari A.
Publication year - 2010
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.b4824
Subject(s) - medicine , trimethoprim , placebo , sulfamethoxazole , oral administration , anesthesia , antibiotics , pathology , alternative medicine , microbiology and biotechnology , biology
Fifteen New Zealand white rabbits were used in a study to determine whether oral administration of trimethoprim‐sulfamethoxazole affects the rate of tear secretion in healthy rabbits. Ten rabbits received 40 mg/kg trimethoprim‐sulfamethoxazole orally twice a day for 14 days; the other five rabbits were used as a control group and received a placebo during the study. The Schirmer II tear test (STT‐II) was performed in both groups during administration of the drugs or placebo on the first, third, seventh and 14th days. Significant decreases in STT‐II values were observed in the treatment group on the 14th day of the study in comparison with baseline values (P<0.001).