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Effects of a modified live CSFV vaccine on the development of PMWS in pigs infected experimentally with PCV‐2
Author(s) -
Ha Y.,
Lee EM.,
Lee Y. H.,
Kim C. H.,
Kim D.,
Chae S.,
Ahn K. K.,
Kim B.,
Chae C.
Publication year - 2009
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.164.2.48
Subject(s) - porcine circovirus , classical swine fever , virology , wasting syndrome , virus , lymph , vaccination , circovirus , biology , medicine , immunology , wasting , pathology
The objective of this study was to determine the effect of vaccination against classical swine fever virus (CSFV) on the development of postweaning multisystemic wasting syndrome (PMWS) in conventional pigs infected experimentally with porcine circovirus type 2 (PCV‐2). The pigs infected with PCV‐2 and immunised with modified live CSFV developed mild to moderate PMWS, whereas none of the pigs infected with PCV‐2 alone or immunised with modified live CSFV alone developed PMWS. Lesions histologically characteristic of PMWS were observed in lymph nodes from the pigs infected with PCV‐2 and immunised with modified live CSFV vaccine, and extensive replication of PCV‐2 was detected in the nodes by in situ hybridisation.