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E‐cadherin expression in canine cutaneous histiocytomas
Author(s) -
Baines S. J.,
McInnes E. F.,
McConnell I.
Publication year - 2008
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.162.16.509
Subject(s) - cadherin , immunohistochemistry , epidermis (zoology) , pathology , cell adhesion molecule , flow cytometry , langerhans cell , biology , antigen , cell , medicine , microbiology and biotechnology , immunology , anatomy , genetics
Canine cutaneous histiocytoma is a common skin tumour of Langerhans cell origin. Langerhans cells are members of the dendritic cell family of antigen‐presenting cells and are located in the epidermis. They are unique among the dendritic cell lineage in that they express high levels of the adhesion molecule E‐cadherin. The expression of E‐cadherin by the neoplastic Langerhans cells in 37 dogs with cutaneous histiocytoma was studied by flow cytometry and immunohistochemistry. In all the cases, these cells expressed E‐cadherin, whereas the infiltrating lymphocytes did not.