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Clinical and anti‐inflammatory effects of treating endotoxin‐challenged pigs with meloxicam
Author(s) -
Friton G. M.,
Schmidt H.,
Schrödl W.
Publication year - 2006
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.159.17.552
Subject(s) - meloxicam , lipopolysaccharide , medicine , placebo , pharmacology , pathology , alternative medicine
The clinical and anti‐inflammatory effects of a single treatment of 0·4 mg meloxicam/kg bodyweight on pigs that had been challenged with Escherichia coli endotoxin were investigated. Significantly lower total clinical scores were recorded in pigs treated with meloxicam than in pigs treated with a placebo. Significantly higher mean serum concentrations of thromboxane B 2 were also recorded in pigs treated with a placebo for up to 24 hours after the challenge. The serum concentrations of acute phase proteins and specific antibody titres to E coli lipopolysaccharide were unaffected by the meloxicam. The meloxicam treatment was well tolerated.