Premium
Histiocytic sarcoma of the spleen in flat‐coated retrievers with regenerative anaemia and hypoproteinaemia
Author(s) -
Dobson J.,
Villiers E.,
Roulois A.,
Gould S.,
Mellor P.,
Hoather T.,
Watson P.
Publication year - 2006
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.158.24.825
Subject(s) - histiocytic sarcoma , spleen , histiocyte , pathology , splenectomy , medicine , sarcoma , immunology
Three flat‐coated retrievers with a regenerative anaemia were examined. They were hypoproteinaemic suggesting that the anaemia might be due to blood loss, but it was not possible to identify a site of haemorrhage. All three had splenomegaly with splenic abnormalities apparent on ultrasonography. Ultimately all three animals were shown to have a histiocytic sarcoma involving the spleen and other tissues. A fourth flat‐coated retriever with anaemia, hypoproteinaemia and an abdominal mass was also diagnosed with a histiocytic sarcoma of the spleen following splenectomy. It is postulated that the dogs’ anaemia was due to erythrophagocytosis, either directly by neoplastic cells or by reactive macrophages.