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Plasma 14 C‐cholic acid clearance in healthy dogs and dogs with cholestasis or a congenital portosystemic shunt
Author(s) -
Bosje J. T.,
Bunch S. E.,
Brom W.,
Rothuizen J.
Publication year - 2005
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.157.4.109
Subject(s) - cholic acid , portosystemic shunt , cholestasis , bile acid , enterohepatic circulation , neonatal cholestasis , medicine , plasma clearance , shunting , clearance , bilirubin , gastroenterology , endocrinology , chemistry , pharmacokinetics , cirrhosis , urology , portal hypertension , biliary atresia , transplantation , liver transplantation
The clearance profiles of intravenously injected tracer doses of radioactively labelled cholic acid were investigated in healthy dogs, dogs with a congenital portosystemic shunt and dogs with cholestasis. The rate constants and residual plasma activity were significantly different in the healthy and diseased dogs, but it was not possible to differentiate between the dogs with portosystemic shunting and cholestasis because the results were determined not only by factors involved in plasma bile acid clearance but also by the enterohepatic circulation.