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Protection of dogs for 13 months against Bordetella bronchiseptica and canine parainfluenza virus with a modified live vaccine
Author(s) -
Jacobs A. A. C.,
Theelen R. P. H.,
Jaspers R.,
Horspool L. J. I.,
Sutton D.,
Bergman J. G. H. E.,
Paul G.
Publication year - 2005
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.157.1.19
Subject(s) - bordetella bronchiseptica , nasal administration , bordetella , virology , virus isolation , medicine , pathogen , virus , isolation (microbiology) , specific pathogen free , biology , microbiology and biotechnology , bacteria , genetics , bordetella pertussis
Twelve specific pathogen‐free ( SPF ) puppies were vaccinated intranasally with a bivalent, modified live vaccine against infectious tracheobronchitis (group 1) and six puppies of the same age and from the same source served as unvaccinated controls (group 2). Both groups were challenged with wild‐type Bordetella bronchiseptica and canine parainfluenza virus by the aerosol route 56 weeks after group 1 had been vaccinated, and at the same time six 10‐week‐old SPF puppies from the same source (group 3) were also challenged. Oronasal swabs were taken regularly before and after the challenge, for the isolation of bacteria and viruses, and the dogs were observed for clinical signs for three weeks after the challenge. The control dogs became culture‐positive for B bronchiseptica and canine parainfluenza virus, but the isolation yields from the vaccinated group were significantly lower (P<0·05). The mean clinical scores of the vaccinated group were 61 per cent lower than the scores of group 2 (P=0·009), and 90 per cent lower than the scores of group 3 (P=0·001).