Premium
Serum activity/concentration profiles of a sustained‐released formulation of sulphathiazole‐trimethoprim (2·5:1) in calves
Author(s) -
Sumano H.,
Gutierrez L.,
Zamora M. A.,
Perez M.,
Cruz C.
Publication year - 2004
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.155.21.672
Subject(s) - group b , trimethoprim , bolus (digestion) , group a , medicine , zoology , chemistry , anesthesia , antibiotics , biology , biochemistry
Thirty‐six two‐week‐old healthy Holstein‐Friesian calves weighing between 52 and 58 kg were divided at random into three groups of 12; group A calves were given a single oral bolus containing 2.5 g sulphathiazole and 1 g trimethoprim in a sustained‐release formulation; group B received the same doses of the drugs but the trimethoprim was not in a sustained‐release formulation; group C received a bolus containing 2.5 g sulphathiazole and 0.5 g conventional trimethoprim. Blood samples were collected at intervals for two days, the serum was separated and the composite antibacterial activity profiles of the mixture were analysed by an agar‐diffusion microbiological method. The mean maximum activities in the serum of the three groups were 23.4 μg/ml in group A, 9.25 μg/ml in group B and 8.01 μg/ml in group C. The mean areas under the curves of the serum activity time curves were 838 μg/ml/hour in group A, 216 μg/ml/hour in group B and 182 μg/ml/hour in group C.