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Urinary corticoid:creatinine ratios in healthy pet dogs after oral low‐dose dexamethasone suppression tests
Author(s) -
Vaessen M. M. A. R.,
Kooistra H. S.,
Mol J. A.,
Rijnberk A.
Publication year - 2004
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.155.17.518
Subject(s) - dexamethasone , creatinine , medicine , urinary system , endocrinology , dexamethasone suppression test , oral dose , urine , oral administration
Eleven dogs were used in a trial to find a suitable dose of dexamethasone for an oral dexamethasone suppression test for the diagnosis of hyperadrenocorticism. Basal urinary corticoid:creatinine ratios were established in all 11 and then groups of seven were given oral doses of 0.02, 0.01 or 0.0075 mg dexamethasone/kg bodyweight and urine samples were collected at two‐hour intervals from 08.00 to 22.00. The doses of 0.02 and 0.01 mg/kg consistently suppressed their urinary corticoid:creatinine ratios measured at 16.00 by a mean of more than 50 per cent and those of individual dogs to less than 1.0 × 10‐6, whereas the dose of 0.0075 mg/kg did not.