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Biological availability of inhaled fluticasone propionate in horses
Author(s) -
Laan T. T. J. M.,
Westermann C. M.,
Dijkstra A. V.,
van Nieuwstadt R. A.,
FinkGremmels J.
Publication year - 2004
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.155.12.361
Subject(s) - fluticasone propionate , bioavailability , evening , placebo , fluticasone , morning , endogeny , medicine , nasal spray , hydrocortisone , drug , nasal administration , horse , pharmacology , physiology , inhalation , anesthesia , biology , paleontology , physics , alternative medicine , pathology , astronomy
Healthy horses received aerosolised, intranasal or oral doses of 3 mg of fluticasone propionate evenly divided over morning and evening treatments for seven days. The bioavailability of the drug was determined in terms of the suppression of the endogenous cortisol concentrations in the horses during the period of treatment. The horses which received the aerosolised drug had significantly lower concentrations of endogenous cortisol on days 5 and 8 than the horses which received aerosolised placebo. The horses which received nasal and oral doses of fluticasone propionate showed no significant changes in their endogenous cortisol concentrations.