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Field trial of the efficacy of a combination of ivermectin and praziquantel in horses infected with roundworms and tapeworms
Author(s) -
Barrett E. J.,
Farlam J.,
Proudman C. J.
Publication year - 2004
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.154.11.323
Subject(s) - praziquantel , ivermectin , veterinary medicine , antibody , helminthiasis , biology , cestoda , anthelmintic , helminths , antigen , parasite hosting , feces , medicine , gastroenterology , immunology , microbiology and biotechnology , schistosomiasis , world wide web , computer science
Two hundred and thirty‐three horses were screened for the presence of roundworms by faecal egg counts (FEcs) and for tapeworms by an ELISA specific for antibodies to the immunodominant 12 kDa and 13 kDa tapeworms antigen. The 62 horses were found to be infected with both parasites were treated with a combination of 0.2 mg/kg ivermectin and 1.5 mg/kg praziquantel. The treatment suppressed the median FEC of the horses to zero for 10 weeks and significantly reduced their anti‐12/13 kDa antibody levels. The estimated risk of tapeworm‐associated colic in these horses was halved by 12 weeks after the treatment.