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Experimental Corynebacterium pseudotuberculosis mastitis in dairy cows
Author(s) -
Aroch I.,
Harmelin A.,
Saran A.,
Levin D.,
Shpigel N. Y.
Publication year - 2003
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.153.24.746
Subject(s) - neutrophilia , corynebacterium pseudotuberculosis , mastitis , inoculation , caseous lymphadenitis , medicine , veterinary medicine , corynebacterium , lymph , biology , pathology , immunology , bacteria , genetics
The inoculation of 2000 colony‐forming units of Corynebacterium pseudotuberculosis into one teat canal of each of three cows resulted in severe, chronic, pyogranulomatous mastitis. Within three days the cows had a reduced haematocrit, haemoglobin concentration and red cell count. The anaemia was initially normocytic, normochromic and non‐regenerative, and was associated with a brief peak of neutrophilia; a regenerative response became evident two to three weeks later. Clinical signs of mastitis appeared seven to 14 days after the inoculation, with a peak of high fever, more severe anaemia, a second peak of neutrophilia and the complete cessation of milk production from all quarters; extensive and severe pyogranulomatous mastitis developed in the inoculated quarters. No other lesions were detected postmortem, and C pseudotuberculosis was cultured from the affected quarters but not from the supramammary lymph nodes and viscera.